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In 1828 Andrew Jackson won the presidential election with a clear majority of both popular and electoral votes.
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Native Americans were most negatively affected by manifest destiny because these people were forcibly removed from their native lands and homes. This was envisioned by Thomas Jefferson and structured by James Monroe in the Indian Removal Act of 1830. This is also where the “Trail of Tears” emerges from as Native Americans suffered, died, starved, and became ill from the removal out of their homes.