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Many died of diseases brought by the Europeans. This was the main impact of these voyages in the very short term. Later, Columbus's voyages led to the domination of the area from Mexico south to Peru by the Spanish. This resulted in the destruction of the major native civilizations like the Incas and the Aztecs.
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Answer: Yes. This is known as a treaty breach.
If a party has materially violated or breached its treaty obligations, the other parties may invoke this breach as grounds for temporarily suspending their obligations to that party under the treaty. A treaty breach does not automatically suspend or terminate treaty relations, however.