You use a comma if the dependen clause comes first
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Answer:
It depends
If I knew what was inside the box, obviously I would not open it.
If I was asked to store it away, I would not open it. I’d simply forget about the box .
If I were told not to open the box, I probably would.
If I were forbidden to open the box, I definitively would.
Explanation:
Draw your own conclusions.
