During DNA replication, the hydrogen bonds must be broken between the complementary nitrogenous bases in the DNA double helix
Firstly, the enzyme, DNA Helicase breaks the Hydrogen bonds between a specific region of the DNA molecule and unwinds the duplex DNA molecule at the targeted gene sequence site.
Then, RNA Polymerase binds at the 3` site of the gene sequence of the sense/coding strand(only one strand) that acts as the template for mRNA synthesis. RNA Polymerase then matches free nucleotides by complementary base-pairing(A-U & C=G), working in the 5`to3` direction. Hydrogen bonds then form between the complementary bases, holding the nucleotides in place. Each free adjacent nucleotide is joined at 3` ends by Condensation reactions with the other to form Phosphodiester bonds.
Once the mRNA molecule is formed, it is separated from the synthesis complex and leaves the nucleus through pores in the nuclear envelope to moves towards ribosomes for Translation.
Lastly, the DNA double helix rewinds by forming Hydrogen Bonds.
If the live enzyme fructose 1,6- bisphosphatase defect is occured and this results in an abnormally high levels of lactate in the blood plasme this will result into the lactate will accumulate into the blood.
What is the work of fructose 1,6-biphosphatase enzyme?
In the liver, gluconeogenesis converts lactate to glucose. If FBPase-1 is defective, lactate cannot enter the gluconeogenic pathway in hepatocytes, building up in the blood.
A crucial enzyme in gluconeogenesis is fructose 1,6-bisphosphatase (FBPase). It is a possible target for drugs used to treat type II diabetes. Additionally, the protein is linked to a rare genetic metabolic disorder, and certain cancer cells lack the activity of the enzyme FBPase, which encourages glycolysis and aids in the Warburg effect.
To learn more about fructose 1,6-biphosphatase enzyme click the given link
brainly.com/question/13717824
#SPJ4
Your answer would be D :)
