Answer:
The parents are of genotype heterozygous dominant and homozygous recessive. Supposing the dominant allele is N and the recessive allele is n, one of the parents will be Nn while the other nn. The phenotypic (based on visible characteristics) ratio will be 1:1 for dom/rec and rec/rec
Explanation:
Answer:
I get papper plz dont report sorry
Explanation:
P450scc or cholesterol side chain cleavage enzyme is an enzyme that converts cholesterol into pregnenolone (the precursor for steroids). The kinds of steroid hormones are mineralocorticoids (i.e. aldosterone) glucocorticoids (i.e. cortisol), and sex steroids (i.e. testosterone, estrogen). In the event where P450scc is blocked, then there will be no production of mineralocorticoids, glucocorticoids, and sex steroids. There will be no production of aldosterone, cortisol, estradiol, testosterone, and progesterone. This disease is called Lipoid Congenital Adrenal Hyperplasia.
Answer:
1. The difference between the normal hemoglobin protein DNA sequence and the sickle cell hemoglobin DNA sequence is a base to base shift, in this case adenine (GAG) to thymine (GTG).
2. The difference affects the amino acid sequence of the protein by replacing glutamic acid (Glu) with valine (Val).
Explanation:
In sickle cell anemia, a change in the DNA nucleotide sequence is observed, where adenine is substituted by thymine, whose expression is the change in the amino acid sequence of globine β, incorporating valine instead of glutamic acid. This represents a molecular mutation - point mutation - by subtitution, which corresponds to missense mutation.
<u>Normal hemoglobin protein in a RBC</u>
DNA CTG ACT CCT GAG GAG AAG TCT
Amino acids Leu Thr Pro Glu Glu Lys Ser
<u>Sickle cell hemoglobin protein in a RBC</u>
DNA CTG ACT CCT <em>GTG</em> GAG AAG TCT
Amino acids Leu Thr Pro <em>Val</em> Glu Lys Ser
When GAG is transcribed to mRNA, the CUC codon is obtained, which codes for glutamic acid. Thymine substitution causes the DNA sequence to change to GTG, which is transcribed as CAC, the codon that encodes the amino acid valine. The <u>change from glutamic acid to valine in β-globin causes an altered hemoglobin, giving the abnormal erythrocytes observed in sickle cell disease</u>.
