The answer would be D: Leader of Al-Qaeda
I'm not sure if this is correct, but I believe that establishing a government was a major issue. Deciding how the government should be run took a while to figure out, and many drafts to get the final Constitution.
Hope this helps! Correct me if I'm wrong!
The answer that best fits the blank provided is "20TH CENTURY". It was during the 20th century that Aspirin was discovered, specifically, in the year 1897 by <span>Felix Hoffmann, a German Chemist. For them, it was the most useful during this time in order to relieve pain.</span>