You should give options, but i think that "Health care is one of the services that would not fall under WTO jurisdiction. The full form of WTO is World Trade Organization."
The answer to your question would be fracture
Italy is surrounded by sea, meaning that there is always accessible trade routes through water. In earlier days, water trade routes became much more popular due to not having to travel through rough terrain. Therefore, the economy boosted as trade increased.
The population had a short increase, then a more sustained decrease. it has to do to their beak depths.
The use of machinery made work easier and more efficient, therefore more raw materials were needed because final products could be produced much faster.