I'm thinking (C) but i'm not for sure!?!
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After the invention of the cotton gin in 1793, the economies of the Upcountry and the Low country of the state became fairly equal in wealth. The expansion of cotton cultivation upstate led to a marked increase in the labor demand, with a concomitant rise in the slave trade.
<span> A tissue or organ on which a hormone exerts its action; generally, a tissue or organ with appropriate receptors for a hormone</span>