<em>The first stages of the decline of the Roman Empire (AD 108) coincided with a large-scale epidemic </em>This is the correct option.
This statement provides evidence of the way in which small-pox affected the Western civilization . The Roman Empire was part of the Western civilization and it started to fall down at the same time a severe epidemy of chicken pox was spreading.
These options are not right:
- Smallpox was introduced to Europe sometime between the fifth and seventh centuries. . . ( This evidende refers to the time it was introduced in Europe , not to the development of the Western civilization.)
-The Arab expansion, the Crusades, and the discovery of the West Indies all contributed to the spread of the disease. ( This evidence talks about the factors that spread the disease, not about the effect it had on the development of the Western civilization).
-Unknown in the New World, smallpox was introduced by the Spanish and Portuguese conquistadors ( This refers to the first time chicken -pox had become known.)