Question

Tay-Sachs disease is caused by a mutation in the HEXA gene located on chromosome 15. Tay-Sachs follows an autosomal recessive pattern of inheritance. With the help of the diagram, identify which of the offspring will be an unaffected carrier.
A.A, B, and C
B. B and C
C. A and D
D. A
E. D

Answer 1

The unaffected carrier individual, is the one who has only mutated gene of the autosomal recessive disease.

The right answer is B and C individuals

The genes responsible for autosomal recessive (AR) transmitted diseases are localized on autosomes.

The mutated allele responsible for the disease is recessive on the wild allele; heterozygotes are healthy and the disease is expressed only in homozygotes.

Tay-Sachs disease is a neurodegenerative disease caused by a deficiency of hexosaminidase causing an accumulation of ganglioside GM2.

Answer 2

the right answer is b and c