Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
The nurse uses a variety of therapeutic communication skills when working with clients. Assess the client's perception of a problem is a therapeutic goal that can be accomplished through the use of therapeutic communication skills.
A group of methods known as therapeutic communication put the patients' physical, mental, and emotional well first. While maintaining a level of professional distance and objectivity, nurses support and enlighten patients.
Therefore, the goal of therapeutic communication is to support clinicians in establishing trust with patients while also assisting patients and clinicians in working effectively and efficiently together to promote the patient's physical and emotional welfare.
When the same nurse asks the patient if they have any questions or concerns, explains why they are completing the chores, speaks in a friendly and inviting tone, and shows the patient through body language that their opinions are appreciated, that is an example of therapeutic nursing communication.
Learn more about therapeutic communication here:
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Answer:
A vaccinations helps your body build up an immune system to that sickness. Personal health choices can be anything from washing your hands, to wearing a mask in the store.
Explanation:
