Mike's intrapulmonary pressure must be lower than atmospheric pressure when he inhales and greater than atmospheric pressure when he exhales in order to maintain normal air flow during inhalation and exhalation when he is having one of his asthma attacks.
The pressure exerted by gases within the alveoli of the lungs is called as intrapulmonary pressure.
To secure the normal air flow, the pressure gradient increases as airway resistance also increases. The pressure gradient is the difference between intrapulmonary and atmospheric pressures.
During inhalation, the intrapulmonary pressure must decrease more than average so that air is carried into the lungs against a greater resistance. However, during exhalation, the intrapulmonary pressure must increase more than normal to move out the air against the same resistance.
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Cholesterol (especially LDL*) tend to get into macrophages which migrate into blood vessels. Macrophages with cholesterol cannot get out of the vessels and stay there which causes a lipid mass in arteries. That causes atherosclerosis.
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