Question

The frequency of sickle-cell anemia, an autosomal recessive condition, is 0.007. Assuming that the population is in H-W equilibrium, what is the frequency of the recessive allele that causes the condition? Enter your answer to the nearest 0.001.

Answer 1

Answer:

The correct answer is - 0.084

Explanation:

Sickle cell anemia is a autsmal recessive blood disorder of RBCs where RBC shape altered to the sickle shape or cresecent moon that obstruct and damage the veins and artries.

Normal allele is represented by - HbA - p

sickel cell allele is represented by - HbS - q

genotype frequency of normal allele HbA in the population = p2

genptype frequency of HbAHbS in the population = 2pq

genotype frequency of autosomal recessive HbS = q2 = 0.007 (given)

So, the allelic frequency of the recessive allele =

q =  √ 0.007 = 0.08366 or 0.084