Answer:
Since sickle cell disease is a disorder with an autosomal dominant inheritance pattern, and in light of the lack of data, it could be said that the only way for Pat and Tracy to have a child with sickle cell disease is for both of them to be healthy carriers of the gene, with a 25% probability.
Explanation:
Considering that both Pat and Tracy each have a sibling with a sickle cell trait and that both they and their parents are healthy, it must be assumed that some of their parents are healthy carriers:
- Pat and Tracy do not have sickle cell trait. In this case, there is no chance that they will have a child with sickle cell disease.
- Either Pat or Tracy has the trait, but the other does not. It is possible that at least one of their children is a healthy carrier.
- If both Tracy and Pat have sickle cell trait, the chances of having a child with sickle cell disease are:
Alelles R r
R RR Rr
r Rr rr
RR: healthy (25%).
Rr: healthy carrier (50%).
rr: sickle cell disease (25%).
<em>If Pat and Tracy are healthy carriers of the gene that determines sickle cell disease, the chance of having a child with the disease is 25%</em>.
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