I believe it was a trade route that was used commercially. Traders often used this route because it stretched so long and wide across the US.
Answer:
The War of 1812 ensure the position as Independent country of United States.
Explanation:
The War of 1812 main cause was the non-acceptance of United States as an independent country by England. This war was not conclusive, meaning that neither party declared victory or defeat.
The war brought positive effects like the increase of manufacture as the US stop importing merchandise from Europe. In the domestic politics scenario, it marked the end of the Federalist party who sided with Britain it was composed by the wealthy elites of society, while the Democrat-Republicans favored France and were the more for the "common man".
The right answer is the third one: the bubonic plague originated in the Gobi Desert, part of the then Mongol Empire, around 1320. It then propagated to China and subsequently to India, Europe and Russia. The disease spread via trade routes mainly as a result of a poor hygiene. It never reached the American continent or Sub-Saharan Africa.