I believe the answer is letter D. This being the only one that seems to relate best with the topic sentence.
Answer:
directing and supervising
Based on the question given this is the answer:
He thinks she is worried but optimistic about her husband's
health.
In the central theme of the story, it is given a fact that
the belief of superstitions is something to be afraid of, although people have
taken a wise decision to trust on medicinal treatments.
