They were mostly from Mexico and continued spanish colonization into what is now texas
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In response to Pontiac's Rebellion, a revolt of Native Americans led by Pontiac, an Ottawa chief, King George III declared all lands west of the Appalachian Divide off-limits to colonial settlers. This royal proclamation, issued on October 7, 1763, closed down colonial expansion westward beyond Appalachia.
They felt that they had fought in the French and Indian War in part to drive France out of the west so they could move in. They wanted to get the Indian lands for themselves. Because of this, they protested against the Proclamation of 1763. ... Second, the colonists ignored the proclamation.
Settlers were not to go west of the appalachian mountains. further purchases from indians of land to the east of that line were prohibited. the indian territories west of the proclamation line would be underthe authority of the military.
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The answer to your question is - developing an understanding of the human brain.
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