Answer:
The had large impact as they were the one that eventually defeated and conquered the Empire. Of course, Empire was already in bad condition, but this frequent attacks by the Germanic tribes weakened the Empire furthermore. At the end, Ostrogoths were the one who destroyed Rome in 476.
Explanation:
Namely, after the Great Migration the Germanic tribes started attacking and settling on the soil of the Roman Empire.
They were all pushed by the Huns, who created many problems for Romans. Although, the Huns disappeared from historical theater they already harmed Roman Empire a lot.
Germanic tribes started attacking and settling on the Roman territory. Angles and Saxons settled in England, Vandals in North Africa, Visigoths in Spain.
All of them contributed to the fall of the Empire.