Answer:
I would say c. building and roads systems
During a performance of Henry VIII at the Globe Theater in 1613, a cannon shot an employ for special effects. The theater's cough the thatched roof on fire , burning the original Globe building to the ground.
The most deadly illness the pioneers have faced was Oregon Trail, it was spread by for hunting food, picking berries, and most of all this terrible game kids used to play that made them realize the Oregon Trail was real. It also lead up to bad fever, cholera, and dysentery.
This is the main reason of the deadly illness pioneers had.
Hope this helps you :)
