Answer:
Hibernation is a way animals conserve energy to survive adverse weather conditions or lack of food. It involves physiological changes such as a drop in body temperature and slowed metabolism. Research into the processes involved in hibernation could result in medical benefits for people
Explanation:
Single-cell RNA-sequencing (scRNA-seq) provides the chance to analyze heterogeneous cellular compositions and probe the patterns of gene expression that are unique to each cell type under various circumstances. However, batch effects like lab setups and individual variability make it difficult to use them in cross-condition designs.
<h3>What is Single-cell transcriptomes ?</h3>
In single-cell transcriptomics, the messenger RNA levels of hundreds to thousands of genes are simultaneously measured to assess the degree of gene expression in individual cells within a particular population.
<h3>Advantages : </h3>
• Integrated protocol proceeds directly from whole cells and preserves sample integrity.
• High resolution analysis enables discovery of cellular differences typically hidden by bulk sampling methods.
• Robust transcriptome analysis down to single-cell input levels for high-quality samples.
To know more about Single-cell transcriptome please click here : brainly.com/question/28187739
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<span>Lafora disease is the most severe teenage-onset progressive epilepsy, a unique form of glycogenosis with perikaryal accumulation of an abnormal form of glycogen, and a neurodegenerative disorder exhibiting an unusual generalized organellar disintegration. The disease is caused by mutations of the EPM2A gene, which encodes two isoforms of the laforin protein tyrosine phosphatase, having alternate carboxyl termini, one localized in the cytoplasm (endoplasmic reticulum) and the other in the nucleus. To date, all documented disease mutations, including the knockout mouse model deletion, have been in the segment of the protein common to both isoforms. It is therefore not known whether dysfunction of the cytoplasmic, nuclear, or both isoforms leads to the disease. In the present work, we identify six novel mutations, one of which, c.950insT (Q319fs), is the first mutation specific to the cytoplasmic laforin isoform, implicating this isoform in disease pathogenesis. To confirm this mutation's deleterious effect on laforin, we studied the resultant protein's subcellular localization and function and show a drastic reduction in its phosphatase activity, despite maintenance of its location at the endoplasmic reticulum.
I got my information from </span>https://www.ncbi.nlm.nih.gov/pubmed/14722920
