When it gets too powerful an out-of-control.
Here is a segment of text from the Declaration of Independence
"That whenever any Form of Government becomes destructive of these ends, it is the Right of the People to alter or to abolish it, and to institute new Government, laying its foundation on such principles and organizing its powers in such form, as to them shall seem most likely to effect their Safety and Happiness."
-http://www.ushistory.org/declaration/document/
In the early 1800s, female reformers focused on the issue(s) of: temperance only. women's access to health care and health education. temperance, abolition, and women's access to education.