D.
Source:
https://answers.yahoo.com/question/index?qid=20140322140107AANOiyZ
D) The death toll from the plague led to labor shortages<span />
Answer:
How did the conquest of the Americas affect Spain in the short-term? ... Short term: Natives were sometimes forced to do labor for the Spanish so they hated Spain. Spanish overtake the empires of the Natives. Bottom line, Natives resisted the Spanish.