Nuestro Padre San Francisco de los Tejas was re-established on the west bank of the Neches River in 1716 as the successor to the Mission Tejas, the mission that had been abandoned in 1693. In 1721, the mission was moved to the east bank of the river in what is now Cherokee County and renamed San Francisco de los Neches. The site was about seven miles west of the present-day town of Alto. There is a state historical marker on Texas 21.
Also in 1716, three missions were founded in Nacogdoches County: Nuestra Señora de Guadalupe de los Nacogdoches, Nuestra Señora de la Purísima Concepción de los Hasinai and San José de los Nazonis. In San Augustine County in January 1717, the Franciscans founded Nuestra Señora de Dolores de los Ais.
Mission Concepción de Los Hasinai was located near Douglass, and there is a state historical marker about seven miles south of the town off FM 225.
San José de los Nazonis was in northwest Nacogdoches County. The Texas Department of Transportation has placed a marker about two miles north of the town of Cushing.
In 1719, French incursions from Louisiana caused all the East Texas missions to be temporarily vacated, but they were restored in 1721. While the three missions operated by the Querétero Franciscan college (San Francisco, Concepión, and San José) were removed to Austin in 1730 (see following), Missions Dolores and Guadalupe remained in East Texas until they were abandoned in 1773. Today, there are state historical markers in Nacogdoches and San Augustine commemorating the two missions.
