That one is a struggle but if i had to pick one i think i would do calf 4.
Variations in a genotype could be major or minor. It really depends on the degree of change. A genotype changes due to errors mutations. Some are endogenous, occuring with the organismm often during meiosis that causes changes in a genotype.
Learn more about here: https://www.quora.com/What-causes-variation-in-genotypes-How-does-this-occur
By time......................
A 1000
Hope this helps
Sorry if it was wrong