A) The medical information
Since 1913, the medical knowledge has vastly changed. Medical terms that are today common-knowledge (DNA, chemotherapy, etc.) were not even in existence in 1913.
Hope this helps!!
A. subtle because they're basically making an analogy. For example, some people like cats, while others like dogs. In this case, some people like subtle flavors, while others like spicy hot flavors. Also, none of the other words make sense in the sentence because vivid is usually used to describe colors, universal is used to describe something people do all around the world, and delusional means that you are having thoughts or visions that contradict reality. So, A. subtle is the answer.