You use saber to describe a fact, information, or how to do something.
And you use conocer to say that you are familiar with something either a person, place, or thing.
Basically saber means to know of something, and conocer means to be familiar with someting.
El reloj esta debajo de mi escritorio.
Tu nunca quieres ir al cine
i. yo quiero
you. tu quieres
he/she/it. el/ella quiere
we. nosotros queremos
you. ustedes quieren
they. ellos/ellas quieren