Crossing the Silk Road, Marco Polo brought elements of Western culture to the East and Eastern culture back to the West.
Because of his exploration for trade of what is today modern China, Indonesia, Mongolia, Sri Lanka, and India, the east experienced Western culture.
Furthermore, his journeys were documented in the Book of the Marvels of the World which presented to Europeans the Asian cities and countries.
I believe <span>D. Leonardo da Vinci's Mona Lisa is probably the most famous painting in the world.
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Usually, <em>a disease is considered pandemic</em> when it crosses international borders. A disease that does not cross international borders is an epidemic. An example of a pandemic would be the Black Plague (also called the Black Death or the Bubonic Plague), which <em>killed most of the population of Western Medieval Europe.</em>
Hope this helps!