Question

Hopelessness, difficulty, sadness, defeat

Answer 1

The correct answer for, Which theme can you create using all the key ideas above? is B. With difficulties comes a loss of faith in oneself and in humanity.

Answer 2

I would say that the best theme to address those key points listed, would be: A. Feeling hopeless is unreasonable when faced with challenges.  In other words, we shouldn't feel as if the end of that world is at hand, just because challenges and tests come our way.  That is to be expected.  Hope that helps.