2 and 3 are too similar to distinguish because they both are saying it's been back up on several different accounts but 3 seems like a more solid answer go with 3
Answer:
Amino acid substitutions at the interaction interface may result in binding affinity changes, and thus affect the structure of the protein complex. ... This structural change may significantly affect the binding energy, and make the protein complex unstable
Explanation:
I hope it helped
This refers to a trait that should be able to be treated with antibiotics but instead the trait has built up a resistance to this trait, sometimes this will even make the trait stronger. This can become fatal if the trait is resistant to all antibiotics available
