Decreasing enzyme binding affinity by blocking the active site.
Answer:
1. P120 is degraded in the 26S proteasome
2. The 26S proteasome has a major role in protein degradation and is critical for protein homeostasis
3. Cell cycle and DNA replication are cellular processes regulated by the Ras and NFkB pathways
Explanation:
The proliferation-associated nucleolar protein (p120) is a protein known to be expressed during the interphase of the cell cycle, specifically in G1 and early S phase, where any problem with DNA replication trigger a checkpoint, i.e., a molecular cascade of signaling events that suspend DNA replication until the problem is resolved. In mammalian cells, the 26S proteasome is responsible for catalyzing protein degradation of about 80% (or even more) of their proteins. The 26S proteasome acts to degrade rapidly misfolded and regulatory proteins involved in the cell cycle, thereby having a major role in protein homeostasis and in the control of cellular processes. It is for that reason that inhibitors that block 26S proteasome function have shown to be useful as therapeutic agents in diseases associated with the failure of protein degradation mechanisms (e.g., multiple myeloma). The NF-κB are highly conserved transcription factors capable of regulating different cellular processes including, among others, cellular growth, inflammatory responses and apoptosis. Moreover, the MAPK/ERK pathway is able to transduce different signals received on the cell surface to the nucleus. The MAPK/ERK pathway is activated when a singling molecule binds to a cell receptor which triggers a signaling cascade that ends when a transcription factor induces the expression of target genes, ultimately producing a response in the cell (for example, the progression through the cell cycle).
Heat from the Sun causes water to evaporate from the surface of lakes and oceans. This turns the liquid water into water vapor in the atmosphere. Plants, too, help water get into the atmosphere through a process called transpiration!
Answer:
MARS
Explanation:
Mars represents the 4th planet of the solar system, being next to the earth. It is comprised of a hard and solid surface and the average surface temperature of Mars is extremely cold, which is roughly about -60°C. The atmosphere of Mars is very thin, which is dominantly comprised of CO₂ gas (almost 95%), along with some molecular Nitrogen (3%) as well as there is the presence of Argon (2%). In addition to this, it is also composed of dust clouds within its atmosphere. There is the absence of a magnetic field in Mars, due to which the solar wind highly affects the atmosphere of Mars.
Copied but correct answer.
Answer: C (She hasn't fastened the slide to the stage
Explanation:
In Microscopy even if the slide is not yet in focus,she will be able to see part of the slide which may appear as transparent image.Therefore this is a wrong answer.
If the microscope is not plugged it light can not come up.
If there are no specimen on the slide,the slide will still as transparent image at the focus.
No doubt Stella forgot to fasten the slide to the stage.,therefore the specimen on the slide was not in focus of the objective lens,rather she was focusing on the stage only,hence the visible white light.
