During the fifteenth-century, Europeans weren't just out to search for a sea route to Asia, they had to search for one since the Ottoman Turks controlled the Silk Road, which was the main land route from Europe through the Middle East to Asia. Europeans had began to demand valuable goods such as silk and spices that could only be found in Asia since it has been quite useful to their daily living. Of course, in turn, European merchants had manufactured goods to sell in Asia for those valuable goods such as silk and spices, but when the land route wasn't available and safe anymore, they had to search for sea routes.
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Douglas alienated Southerners with the Freeport Doctrine, which damaged his chances of winning the Presidency in 1860.
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France feared encirclement by an alliance between Prussia and Spain. Explanation:
