The Proclamation of Neutrality was a formal announcement issued by U.S. President George Washington on April 22, 1793 that declared the nation neutral in the conflict between France and Great Britain. It threatened legal proceedings against any american providing assistance to any country at war.
The trade route to Byzantium is what led to all the others.
Hope this helps :)
~Davinia.
The Santa Fe trail started in Independence, Missouri and ended in Santa Fe, New Mexico (hence the name, Santa Fe). Hope this helped!