The main impact De Soto's expedition was disease.The Native Americans did not have any immunity to European diseases since they had never been in contact with them. The most detrimental of illness was the smallpox. They also were introduced to animals such as horses, war dogs, and pigs.
Its pretty sure that it's , transportation the first one sorry if I'm wrong
The correct answer is C the supreme court i just took the test.
Answer:
The Spanish gained an early foothold in the colonies, quickly becoming the most powerful European power in the New World.
Explanation: