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Answer:
'Pre-Columbian' is a term used to describe the people, history, and cultures of the Americas before Columbus arrived in 1492.
Explanation:
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The most deadly illness the pioneers have faced was Oregon Trail, it was spread by for hunting food, picking berries, and most of all this terrible game kids used to play that made them realize the Oregon Trail was real. It also lead up to bad fever, cholera, and dysentery.
This is the main reason of the deadly illness pioneers had.
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