Question

What explains the observation that a single eukaryotic protein coding gene can give rise to multiple different proteins, i.e., why are there only ~25,000 human genes in the genome, but ~150,000 different proteins in the human "proteome?" choose the two best correct answers?

Answer 1

• Genes can contain more than one polyadenylation site, which alters the 3' of the mRNA transcript and the inclusion/exclusion of exons.
• mRNA transcripts from the same gene can be differentially spliced to include/exclude exons.