For the outline of the prompt, determine your characters, setting, and main focus.
Characters can be anyone you'd like, as long as they are a slave. The setting could be a slave state like Florida or Arkansas in the 1860s. The main focus is what it was like being a slave. Use the resources listed below to study the thoughts and emotions of slaves, and then write from a similar point of view.
http://www.ushistory.org/us/27b.asp
http://blackloyalist.com/cdc/story/revolution/slavery.htm
http://www.eyewitnesstohistory.com/slavelife.htm
http://www.digitalhistory.uh.edu/disp_textbook.cfm?smtID=2&psid=3040
Good luck!
There were of course other factors. While early humans did hunt them a lot due to the profits which they received from it (A lot of food, bones they could use for homes, fur they could use for clothing, etc.), there were also other factors such as less food for them which made them less mobile through different geographical regions, etc. (and therefore more susceptible to being hunted) that had played a part in their extinction.