Answer: The number of available symptomatic treatments has markedly enhanced the care of patients with Amyotrophic Lateral Sclerosis (ALS). Once thought to be “untreatable”, patients with ALS today clearly benefit from multidisciplinary care. The impact of such care on the disease course, including rate of progression and mortality, has surpassed the treatment effects commonly sought in clinical drug trials. Unfortunately, there are few randomized controlled trials of medications or interventions addressing symptom management which has resulted in the need for physicians to base their selection of specific therapies upon personal experience and anecdotal reports (1 Forshew). In this review, we will provide the level of evidence, when available, for each intervention that is currently considered “standard of care” by consensus opinion.
Explanation:
Explanation:
- <em>Presynaptic mechanism:</em> one way to modify the synaptic transmission before it happens is affecting transmitters release, one example is calcium channel blockers (for example, verapamil), this action won't allow transmitters out, therefore, there won't be a synaptic transmission.
- <em>Postsynaptic mechanism:</em> one method to modify synaptic transmission after it happens is blocking the transmitter receptors, one example of this is antipsychotic drugs that block dopamine receptors.
I added some images with another examples for both cases. I hope you find this information interesting! Good luck!
Selective serotonin reuptake inhibitors (ssris) are used to <u>synaptic cleft </u>reuptake and <u>serotonin </u>the amount of serotonin in the cleft.
- Antidepressants known as selective serotonin reuptake inhibitors (SSRIs) are frequently prescribed.
- They are frequently prescribed in conjunction with a talking therapy like cognitive behavioral therapy to treat depression, especially persistent or severe cases (CBT).
- Neurons must be able to communicate with one another in order to convey signals that can be sent throughout the body. Neurons are not merely linked to one another, though.
- A neurotransmitter is typically produced from the axon terminal after an action potential has reached the synapse, the location where neurons can communicate with one another.
learn more about serotonin here:
brainly.com/question/14582277
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Answer:
Explanation:
Their course of action in altering metabolism is very similar because both of them interact with intracellular receptors (primarily the cytosolic receptors present in cytoplasm of the cell) and translocate into the nucleus for performing their desired goal (likely to synthesize a mRNA which can then be turned into a protein to get a desired action going)
Answer:
Gotta love musculoskeletal problems, especially in children.
Explanation:
Vascular impairment and trauma to the bone.
