I am pretty sure that the answer on the first question is poverty, because most rural areas are not as developed as towns.
The second one best matches with physical health, because the physical state has the strongest positions in lige of every alive being.
The next one is the option ''doubled''.
REM sleep's function are that it helps in forming new memories, stimulates the central nervous system, and restores brain chemistry to a normal balance
The mitochondria, in ancient times, used to be a species of it's own. Until one day a unicellular organisms gobbled up a mitochondria and digested it. The mitochondria continued doing it's mechanical functions. (like protein synthesis etc..) Therefore, mitochondria is a living being on it's own sense and hence needs the essential nutrients (like all living beings do) to continue doing it's mechanical functions.
It should be 10% sorry if im wrong :(