Tensions between the United States and the Soviet Union over Cuba had been steadily increasing since the failed April 1961 Bay of Pigs invasion, in which Cuban refugees, armed and trained by the United States, landed in Cuba and attempted to overthrow the government of Fidel Castro
That would be the bubonic plague or the black plague for a more common name.
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I would say that it's B because it appears that the shape of Han China is based off of trade routes.