The Columbus Exchange was a very negative event that had many impacts on natives for what I can see. A very important and major impact this caused was a spread of a disease called smallpox. This disease infected many people part of their community as lead to death in many causing there population to decline quickly. People have even been said to believe that 90% of the natives who got infected with this disease died which can show that it was very deadly. Lucky we do not have to worry about this horrible disease.