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Lyrx [107]
3 years ago
11

A 14-year-old boy develops a pruritic vesicular rash on his face and hands 3 days after hiking in the woods. Which of the follow

ing are most likely to be involved in his illness?
a. Antibody, complement C5-9
b. Circulating immune complexes; complement C5a, neutrophils
c. Cytotoxic T lymphocytes
d. IgE, mast cells, histamine, cytokines
e. Lymphocytes, cytokines, macrophages
Biology
1 answer:
zysi [14]3 years ago
3 0

Answer:

The correct answer is: E) Lymphocytes, cytokines, macrophages.

Explanation:

Given the symptoms and how much time they took to appear, the 14-year-old boy seems to be having delayed-type hypersensitivity (also called Type 4 hypersensitivity), causing a reaction called <u>Contact Dermatitis</u>. Type 4 is the only type of hypersensitivity that does not require the intervening of an antibody to occur as it happens because of hapten-specific T cells that will generate inflammation and the tissue damage that is usually accompanied by it.

Delayed-type hypersensitivity is characterized for happening at least 48 hours after the contact with the antigen, and will involve activated T lymphocytes (specifically CD4+ Th1), which will secrete cytokines (most importantly Interferon Gamma and IL-2) thus attracting macrophages to the tissue to phagocyte the antigen and produce inflammation.

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