The question is not understandable.
If Macbeth's conscience had caused him no moral suffering, then he would be an out-and-out villain, somewhat like Shakespeare's Richard III. However, Shakespeare wanted to make Macbeth a somewhat sympathetic figure so that his downfall would seem somewhat tragic
In any story, the main character is the protagonist, the central person which the whole story revolves around. Thus, the character who is the main character's opposition is the antagonist
He chased him around with a newspaper and a stick and forced him back into his room.