Big business shaped the American economy in the late 1800s and early 1900s by outproducing smaller "family business," which drove prices down. This happened in large part due to the Industrial Revolution.
Because he sees Japanese as disease from the outside but the communist is a disease from the inside and need to destroy before becoming an unstoppable force. Also the communist is a blocking of his plan to unify China in one flag to defeat the Japanese forces in the country.