The North section of the United States was the one which took
the lead in demanding tax on manufactured goods going in the United Stated from
different foreign countries. Civil war in 1861 started because of sectional differences
between North and South.
I believe that the primary reason was guns since the Incas were unarmed
Spanish exploration in the americas increased greatly during the 1500s
During this period, they managed to conquered almost all region of Brazil, which bring them a vastly amount of natural resources of Agricultural products such as coffee, latex, and spices.
hope this helps