Answer:
apply oxygen via nonrebreathing mask, start an IV with normal saline, and administer 1 mg of epinephrine 1:10,000 via IV push
Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Answer:
Having knowledge of the law, both federal and state laws, will hopefully prevent you from making a mistake that could cause any form of liability for your employer!
Explanation:
the last thing you would want is for your boss to fire you or charge a patients hospital bill to you because you didn't know that whatever you were doing or prescribing was against the law.
Answer:
As, this individual is expending fructose syrup.
Fructose is changed over to purine which is additionally changed over to uric acid.
Along these lines, more fructose in the eating routine then more purines in the body which will additionally frame progressively uric acid.
This uric acid gathers and causes gout.
What is the best clarification for the introduction of gout right now please clarify why different decisions are not reliable with the information or what extra data you may need to choose the underlying driver?
1. overproduction of purines-They are not being created in the body however yes they are certainly are delivered from the abundance fructose expended.
2. diminished rescue of purines-No, this isn't the main driver.
3. diminished urinary discharge of uric acid this can occur as less uric acid is being discharged in the pee.
When, contrasted with the ordinary individual the patient is discharging less uric acid.
Along these lines, third point is the purpose behind gathering of uric acid in the body.
