It means to restrain yourself from doing something you enjoy
<span>There are several reasons that had led Henrietta and her family in distrusting medical doctors and hospitals. They weren't treated properly and they weren't being given/told the truth. Throughout Henrietta's life after being diagnosed with cancer and through treatment doctors hadn't been telling her everything she should have had the right to know. Then even after Henrietta passed away for a period of time her family still didn't know about the HeLa cells. Henrietta and her family deserved to know all that was happening. Henrietta had a right to be given the choice about giving samples of her cells but she wasn't even told about it. This is what led Henrietta and her family into distrusting medical doctors and hospitals.</span>
The French noticed the strategic importance of the valley as a link in their far-flung empire.
Well, we know that setting is location and surroundings, usually! Irony/sarcasm doesn't apply here, as it's usually in the form of dialogue or much more than those statements.Even if you were confused about tragic resolution, you know enough that there isn't anything particularly 'tragic' nor 'resolving' about this excerpt. So characterization seems best fit, giving an idea on the individual and their attire and how they are interacting with the other! But please, you're free to interpret it yourself in any case if doubtful upon my own.