The use of established trade routes declined.
Answer:Native peoples of America had no immunity to the diseases that European explorers and colonists brought with them. Diseases such as smallpox, influenza, measles, and even chicken pox proved deadly to American Indians. Europeans were used to these diseases, but Indian people had no resistance to them.
Explanation:
Actually the answer is The affranchis and the slaves
I believe it's the first option and the fourth option.
