Answer:
US political parties
Today, America is a multi-party system. The Democratic Party and the Republican Party are the most powerful. Yet other parties, such as the Reform, Libertarian, Socialist, Natural Law, Constitution, and Green Parties can promote candidates in a presidential election.
Explanation:
The smallpox epidemic.
The millitary invasion was devastating but not to the extent of smallpox.
The Jesuits did not really devastate the New World.
Enslavement for sugar plantations mostly occurred with Africans.
Smallpox, brought in by the Columbian Exchange, had a widespread impact that killed a large portion of natives in the Americas.
So the Smallpox epidemic is the answer.
Harrison was the first president to campaign actively for office, he wrote the slogan "Tippecanoe and Tyler too"
Stage crew and electrisonists
Germany has sunk sea vessels regardless of the vessel's nationality.