Answer:
In p53 pathways, 3 proteins which are mutate and cause cancer that proteins are:
1.BRCA2
2. p53 in Rb genes binds with deoxyribonucleic acid that stimulates another gene to produce a protein known as p21 that interacts with cdk2. When p21 is combined with cdk2 cell will not pass through to the next stage of cell division. This is Li-Fraumeni syndrome (when p53 causes cancer from parents to offspring)
3.BRCA1
The parent that transmits mutation in one of these genes has a 50% chance of inheriting the mutation. The effects of mutations in BRCA2 and BRCA1 are seen when the person's second copy of the gene is normal.
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The effect Colchicine might have on dividing cells is that the duplicated chromosomes might not be able to segregate into daughter nuclei.
Colchicine is an alkaloid that attaches to tubulin and prevents it from polymerization to microtubules. As we know that Microtubules are a component of the cytoskeleton of a cell that aids in molecular mobility inside the cell.
During cell division, chromatin condenses into chromosomes, which are then connected to microtubules. The chromosomes are separated into daughter cells by microtubules.
When these cells are treated with colchicine, tubulin polymerization to microtubules may not occur, and the chromosomes containing daughter nucleic might not be separated.
Learn more about chromosomes here:
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