Blood cells use a protein called ________ to capture and carry oxygen

Cystic fibrosis (CF) is one of most common recessive disorders among Caucasians it affects 1 in 1,700 newborns. What is the expe

Phantasy [73]

Answer: The expected frequency of carriers is P(Aa)=0.046.

The proportion of childs with CF is P(aa)=0.024.

25% of having a child with CF (aa).

Explanation:

Hardy-Weinberg's principle states that in a large enough population, in which mating occurs randomly and which is not subject to mutation, selection or migration, gene and genotype frequencies remain constant from one generation to the next one, once a state of equilibrium has been reached which in autosomal loci is reached after one generation. So, a population is said to be in balance when the alleles in polymorphic systems maintain their frequency in the population over generations.

Given the gene allele frequencies in the gene pool of a population, it is possible to calculate the expected frequencies of the progeny's genotypes and phenotypes. <u>If P = percentage of the allele A (dominant) and q = percentage of the allele a (recessive)</u>, the checkerboard method can be used to produce all possible random combinations of these gametes.

Note that p + q = 1, that is, the percentages of gametes A and a must equal 100% to include all gametes in the gene pool.

The genotypic frequencies added together should also equal 1 or 100%, and all the equations can be summarized as follows:

$p+q=1\\(p+q)^{2} = p^{2} +2pq+q^{2} = 1\\P(AA)=p^{2} \\P(aa)=q^{2} \\P(Aa)=2pq1$

So, there are 1700 individuals and only one is affected. Since it is a recessive disorder, the genotype of that individual must be aa. So the genotypic frequency of aa is 1/1700=0.000588.

Then, $P(aa)=q^{2}=0.000588$ . And with that we can calculate the value of q,

$P(a)=q=\sqrt{0.000588}=0.024$

And since we know that p+q=1, we can find out the value of p.

$p+0.024=1\\1-0.024=p\\p=0.976$

Next, we find out the genotypic frequency of the genotype AA:

$P(A)=p=0.976\\P(AA)=p^{2} = 0.976^{2}=0.95$

Now, we can find out the genotypic frequency of the genotype Aa:

$P(Aa)=2pq=2 x 0.976 x 0.024 = 0.046$

Notice than:

$p^{2} + 2pq + q^{2} = 1\\x^{2} 0.976^{2} + 2 x 0.976 x 0.024 + 0.024^{2} = 1$

Then, the expected frequency of carriers is P(Aa)=0.046

The proportion of childs with CF is P(aa)=0.024

If two parents are carriers, then their genotypes are Aa.

Gametes produced by them can only have one allele of the gene. So they can either produce A gametes, or a gametes.

In the punnett square, we can see that there genotypic ratio is 2:1:1 and the phenotypic ratio is 3:1. So, there is a probability of 25% of having an unaffected child, with both normal alleles (AA); 50% of having a carrier child (Aa) and 25% (0.25) of having a child with CF (aa).

5 0

4 years ago

PLEASE HELP

kaheart [24]

Explanation:

C. They make it more fluid

Lipids are composed of fatty acids which form the hydrophilic head and glycerol which forms the hydrophilic tail; their arrangement can give these non-polar macromolecules hydrophilic and hydrophobic properties. Via diffusion, small water molecules can move across the phospholipid bilayer acts as a semi-permeable membrane into the extracellular fluid or the cytoplasm which are both hydrophilic and contain large concentrations of polar water molecules or other water-soluble compounds.

The hydrophilic heads of the bilayer are attracted to water while their water-repellent hydrophobic tails face towards each other- allowing molecules of water to diffuse across the membrane along the concentration gradient.

Transmembrane proteins are embedded within the membrane from the extracellular fluid to the cytoplasm, and are sometimes attached to glycoproteins (proteins attached to carbohydrates) which function as cell surface markers. Cholesterol, which is comparatively rigid, anchors other molecules attached to the membrane, maintain membrane stability or structural integrity and aid in separating some lipids, helping with membrane fluidity at low environmental temperatures.

Membrane components brainly.com/question/1971706

Learn more about plasma membrane transport brainly.com/question/11410881

#LearnWithBrainly

3 0

4 years ago

Once assembled, what is the key to a protein's unique function?

Airida [17]

Answer:

Once assembled, what is the key to a protein's unique function? The manner in which proteins fold is the key to their function

7 0

3 years ago

The term for the skin surface supplied by a single afferent nerve is: